Canine NT-proBNP
The NT-ProBNP test is a diagnostic tool used to measure levels of N-terminal pro-B-type natriuretic peptide (NT-ProBNP), a biomarker released by cardiac muscle cells in response to stretching and stress. Elevated NT-ProBNP levels are indicative of heart disease and can be used to assess the severity of cardiac conditions, including congestive heart failure, myxomatous mitral valve degeneration (MMVD) and dilated cardiomyopathy (DCM). This test is particularly valuable in early detection of heart disease in dogs and cats, enabling veterinarians to initiate treatment before symptoms progress significantly. NT-ProBNP testing also aids in distinguishing cardiac from respiratory disease.
Test name
Canine NT-ProBNP
Test Code
3007
Section
Endocrinology
Species
Canine
Specimen
2 ml EDTA Plasma
Collection Guidelines
- Collect blood using an appropriate EDTA (Purple-Top) vacutainer tube.
- Centrifuge the sample to separate the plasma. Transfer the clear plasma into a new, leak-proof plain EDTA tube and label it as “Plasma.”
- Avoid using excessively hemolyzed samples, as they are unsuitable for this test.
- Unspun samples will not be accepted.
- Refrigerate the sample at 4°C until shipment.
Turnaround time
14-21 days
Packing Instructions
Label each sample with the animal’s name and a unique identifier, using a permanent marker or a secure adhesive label. Ensure the submittal form is completed with the animal’s information and relevant medical history.
References
- Fox, P.R., et al. “Clinical Relevance of NT-ProBNP Testing in Diagnosing Feline and Canine Heart Disease.” Journal of Veterinary Internal Medicine, 2021.
- Oyama, M.A., et al. “Utility of NT-ProBNP as a Biomarker for Heart Disease and Heart Failure in Veterinary Patients.” Veterinary Clinics of North America: Small Animal Practice, 2022.
- Stepien, R.L., & Visser, L.C. “Advances in Cardiac Biomarkers: The Role of NT-ProBNP in Veterinary Cardiology.” Journal of Veterinary Diagnostic Investigation, 2023.
