Parathyroid Hormone (PTH) & Ionized Calcium Profile – Equine
The Parathyroid Hormone (PTH) and Ionized Calcium Profile is a comprehensive diagnostic tool used to evaluate calcium homeostasis and parathyroid gland function in horses. Calcium is a vital mineral involved in numerous physiological processes, including muscle contraction, nerve transmission, and bone health. PTH, secreted by the parathyroid glands, regulates blood calcium levels by influencing bone resorption, renal calcium reabsorption, and vitamin D activation. Abnormalities in PTH and ionized calcium levels can indicate various metabolic and endocrine disorders. This profile is particularly useful in diagnosing conditions such as nutritional secondary hyperparathyroidism (Big Head Disease), hypercalcemia of malignancy, hypocalcemia associated with lactation or exertional rhabdomyolysis, and other disorders affecting calcium metabolism. Measuring ionized calcium provides a direct assessment of the biologically active form of calcium, while PTH levels indicate the glandular response to changes in calcium status.
Test name
Parathyroid Hormone (PTH) & Ionized Calcium Profile – Equine
Test Code
E146
Section
Endocrinology
Species
Equine
Specimen
2 ml Fasting Serum
Collection Guidelines
- Collect an adequate amount of blood in a plain red-top tube or serum separator tube (yellow-top tube). Allow it to clot at room temperature for 30 to 60 minutes before separation.
- Centrifuge to separate the serum. Transfer the clear serum into a new, leak-proof plain red-top tube and label it as “serum.”
- Excessively hemolyzed samples are not suitable for this test.
- Unspun samples will not be accepted.
- Refrigerate sample at 4oC until shipment.
Turnaround time
14-21 days
Packing Instructions
Label each sample with the animal’s name and a unique identifier, using a permanent marker or a secure adhesive label. Ensure the submittal form is completed with the animal’s information and relevant medical history.
References
- Toribio, R.E., et al. “Equine Calcium and Parathyroid Hormone Dynamics: Diagnostic and Clinical Applications.” Journal of Equine Veterinary Science, 2021.
- Schott, H.C., et al. “Endocrine and Metabolic Disorders in Horses: Focus on PTH and Calcium Regulation.” Veterinary Clinics of North America: Equine Practice, 2022.
- Adams, A.P., et al. “Advances in the Diagnosis of Calcium Disorders in Equine Patients.” Journal of Veterinary Diagnostic Investigation, 2023.
