Equine Granulosa Cell Tumor Panel
The Equine Granulosa Cell Tumor Panel is a diagnostic tool used to evaluate hormonal levels in mares for the diagnosis of granulosa-theca cell tumors (GCTs), the most common ovarian tumors in equines. This panel measures anti-Mullerian hormone (AMH), inhibin, and testosterone, which are key biomarkers associated with Granulosa Cell Tumor. These tumors disrupt normal ovarian function, often leading to reproductive and behavioral abnormalities. Mares with Granulosa Cell Tumor frequently exhibit clinical signs such as persistent estrus, infertility, and stallion-like behavior due to elevated testosterone levels. Increased inhibin concentrations suppress follicle-stimulating hormone (FSH) production, resulting in inactivity of the contralateral ovary, while high AMH levels serve as a highly sensitive and specific indicator of GCTs. The Equine Granulosa Cell Tumor Panel is minimally invasive and provides veterinarians with critical insights for confirming a diagnosis and planning treatment, which often involves surgical removal of the affected ovary.
Test name
Equine Granulosa Cell Tumor Panel
Test Code
E123
Section
Endocrinology
Species
Equine
Specimen
2 ml Serum
Collection Guidelines
- Collect an adequate amount of blood in a plain red-top tube or serum separator tube (yellow-top tube). Allow it to clot at room temperature for 30 to 60 minutes before separation.
- Centrifuge to separate the serum. Transfer the clear serum into a new, leak-proof plain red-top tube and label it as “serum.”
- Excessively hemolyzed samples are not suitable for this test.
- Unspun samples will not be accepted.
- Refrigerate sample at 4oC until shipment.
Turnaround time
14-21 days
Packing Instructions
Label each sample with the animal’s name and a unique identifier, using a permanent marker or a secure adhesive label. Ensure the submittal form is completed with the animal’s information and relevant medical history.
References
- Ball, B.A., et al. “Hormonal Biomarkers for Diagnosing Granulosa Cell Tumors in Mares.” Journal of Equine Veterinary Science, 2021.
- McCue, P.M., et al. “The Role of Anti-Mullerian Hormone, Inhibin, and Testosterone in the Diagnosis of Equine Ovarian Tumors.” Veterinary Clinics of North America: Equine Practice, 2022.
- Claes, A., et al. “Advances in the Diagnosis and Management of Equine Granulosa Cell Tumors.” Journal of Veterinary Diagnostic Investigation, 2023.
