Epilepsy Therapeutic Panel
The Epilepsy Therapeutic Panel is a comprehensive diagnostic tool designed to monitor and manage epilepsy treatment in veterinary patients. This panel quantifies the serum concentrations of key antiepileptic drugs, including Bromide (measured by UV/Vis spectrophotometry), Levetiracetam (analyzed using Liquid Chromatography-Mass Spectrometry, LC/MS), Phenobarbital (via LC/MS), and Zonisamide (via LC/MS). The panel enables precise therapeutic drug monitoring (TDM), ensuring efficacy while minimizing toxicity.
Test name
Epilepsy Therapeutic Panel
Test Code
8024
Section
Analytical Chemistry
Species
Canine and Feline
Specimen
2 ml Serum
Collection Guidelines
- Collect an adequate amount of blood in a plain red-top tube or serum separator tube (yellow-top tube). Allow it to clot at room temperature for 30 to 60 minutes before separation.
- Centrifuge to separate the serum. Transfer the clear serum into a new, leak-proof plain red-top tube and label it as “serum.”
- Excessively hemolyzed samples are not suitable for this test.
- Unspun samples will not be accepted.
- Refrigerate sample at 4oC until shipment.
Turnaround time
14-21 days
Packing Instructions
Label each sample with the animal’s name and a unique identifier, using a permanent marker or a secure adhesive label. Ensure the submittal form is completed with the animal’s information and relevant medical history.
References
- Trepanier, L. A., & Van Schoick, A. (2021). Monitoring Antiepileptic Drugs in Veterinary Medicine: Current Practices and Future Directions. Journal of Veterinary Internal Medicine, 35(4), 1421–1430.
- Podell, M., Volk, H. A., & Berendt, M. (2016). 2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs. Journal of Veterinary Internal Medicine, 30(2), 477–490.
- Packer, R. M. A., & Volk, H. A. (2015). Epilepsy in Companion Animals: A Comparative Review of the Impact on the Owner and the Animal. Veterinary Record, 177(8), 203–209.
