Mast Cell Tumor Prognostic Panel
The Mast Cell Tumor Prognostic Panel is a comprehensive diagnostic tool designed to assess the biological behavior and potential aggressiveness of mast cell tumors in canines. This panel includes several key evaluations: immunohistochemistry (IHC) for C-Kit and Ki-67, PCR for C-Kit mutations in Exon 8 and Exon 11, and AgNOR (argyrophilic nucleolar organizer region) special staining.
Section
Cancer Diagnostics
Test Code
1007
One of the following: fixed tissue in 10% formalin, paraffin embedded tissue, or 3 unstained formalin-fixed tissue sections on positively charged slides. Slide preparation using submitted tissue will incur additional charges.
Tissue: Samples must be submitted in sealed, leak-proof, wide-mouth plastic containers. Glass containers are not acceptable and will incur an additional processing fees.
Slides: Samples should be submitted in designated slide containers.
Label each sample with the animal’s name and a unique identifier, using a permanent marker or a secure adhesive label.
Ensure the submittal form is completed with the animal’s information and relevant medical history.
Blackwood, L., et al. "Mast Cell Tumors in Dogs: Histological and Molecular Markers of Prognosis." Veterinary Pathology, 2021.
London, C.A., et al. "Mutation of C-Kit in Canine Mast Cell Tumors: Implications for Therapy." Journal of Veterinary Internal Medicine, 2022.
Kiupel, M., et al. "Prognostic Significance of AgNOR and Ki-67 in Canine Mast Cell Tumors." Journal of Comparative Pathology, 2023.