Parathyroid Hormone related protein (PTHrp)
Parathyroid hormone-related protein (PTHrP) is a diagnostic biomarker often evaluated in patients suspected of having certain hypercalcemic disorders, including malignancy-associated hypercalcemia. PTHrP testing is particularly useful in identifying paraneoplastic syndromes associated with tumors that secrete PTHrP, as this protein can elevate calcium levels in the bloodstream independently of parathyroid hormone (PTH). Measuring PTHrP levels provides valuable insights into the underlying causes of hypercalcemia, helping to effectively distinguish between primary hyperparathyroidism, neoplastic conditions, and other disorders that impact calcium metabolism.
Test name
Parathyroid Hormone related protein (PTHrp)
Test Code
1017
Section
Cancer Diagnostics
Species
Canine and Feline
Specimen
2 ml EDTA Plasma
Collection Guidelines
- Collect blood using an appropriate EDTA (Purple-Top) vacutainer tube.
- Centrifuge the sample to separate the plasma. Transfer the clear plasma into a new, leak-proof plain EDTA tube and label it as “Plasma.”
- Avoid using excessively hemolyzed samples, as they are unsuitable for this test.
- Unspun samples will not be accepted.
- Refrigerate the sample at 4°C until shipment.
Turnaround time
14-21 days
Packing Instructions
Label each sample with the animal’s name and a unique identifier, using a permanent marker or a secure adhesive label. Ensure the submittal form is completed with the animal’s information and relevant medical history.
References
- Rosol, T.J., & Nagode, L.A. “Hypercalcemia and Parathyroid Hormone-Related Protein in Veterinary Patients.” Veterinary Pathology, 2022.
- Breitschwerdt, E., et al. “PTHrP and Hypercalcemia in Canine and Feline Oncology.” Journal of Veterinary Internal Medicine, 2023.
- Schenker, N.M., et al. “Diagnostic Approach to Hypercalcemia in Veterinary Medicine.” Journal of Veterinary Diagnostic Investigation, 2021.
